Table 2.

Rates of TRV Progression According to Baseline Characteristics

	Levels	N	Rate of Progression of Tricuspid Regurgitant Velocity (m/s/y)	P Valuea
Age (y)	≤75	3,023	0.22 ± 0.09	<0.001
	>75	1,165	0.26 ± 0.09
Sex	Female	2,128	0.24 ± 0.09	0.02
	Male	2,059	0.23 ± 0.09
Body surface area (cm2)	>2	2,684	0.23 ± 0.09	0.30
	≤2	1,504	0.23 ± 0.09
Body mass index (kg/m2)	>30	2,810	0.23 ± 0.09	0.04
	≤30	1,378	0.24 ± 0.09
Left ventricular ejection fraction (%)	<50	576	0.25 ± 0.09	<0.001
	≥50	3,610	0.23 ± 0.09
Baseline TRV (m/s)	>2.8	1,021	0.29 ± 0.09	<0.001
	≤2.8	3,167	0.21 ± 0.08
Right atrial length >5.1 cm	Yes	1,949	0.25 ± 0.09	<0.001
	No	2,623	0.22 ± 0.09
Smoking	Yes	64	0.22 ± 0.09	<0.001
	No	4,124	0.23 ± 0.09
Diabetes	Yes	285	0.26 ± 0.10	0.08
	No	3,903	0.23 ± 0.09
History of acute myocardial infarction	Yes	61	0.28 ± 0.07	<0.001
	No	4,127	0.23 ± 0.09
Hypertension	Yes	570	0.26 ± 0.09	<0.001
	No	3,618	0.23 ± 0.09
Hyperlipidemia	Yes	369	0.25 ± 0.09	0.21
	No	3,819	0.23 ± 0.09
Chronic obstructive pulmonary disease	Yes	82	0.24 ± 0.09	<0.001
	No	4,106	0.23 ± 0.09
Chronic kidney disease	Yes	331	0.26 ± 0.09	0.04
	No	3,857	0.23 ± 0.09
History of ischemic stroke	Yes	26	0.26 ± 0.07	<0.001
	No	4,162	0.23 ± 0.09
Atrial fibrillation	Yes	78	0.27 ± 0.09	<0.001
	No	4,110	0.23 ± 0.09
Heart failure	Yes	312	0.28 ± 0.09	<0.001
	No	3,876	0.23 ± 0.09

Values are mean ± SD progression rates of the peak tricuspid regurgitant gradient within each clinical and echocardiographic subgroup. Only individuals with TRV progression (nonnegative conditional predicted slopes for time) are included.

^aRepresents the P value for the time × variable interaction term.