Table 3.

Mortality Rates and Mortality Risk by Tricuspid Peak Velocity Progression Quartile

Quartile	N	Number of Deaths (N = 947), n (%)	Time to Death (y), Median (IQR)	Unadjusted HR (95% CI) for All-Cause Mortality	P Valuea	Adjusted HR (95% CI) for All-Cause Mortality	P Valueb
1 (0-0.17 m/s/y)	1,048	133 (12.7)	4.9 (2.8-7.3)	Ref	Ref	Ref	Ref
2 (0.18-0.22 m/s/y)	1,046	171 (16.3)	4.1 (2.3-6.6)	1.45 (1.16-1.82)	0.0013	1.41 (1.12-1.78)	0.003
3 (0.23-0.28 m/s/y)	1,047	268 (25.6)	3.9 (1.9-6.2)	2.50 (2.03-3.08)	<0.001	1.95 (1.57-2.43)	<0.001
4 (>0.28 m/s/y)	1,047	375 (35.8)	4.1 (2.4-6.6)	3.44 (2.82-4.19)	<0.001	2.17 (1.74-2.71)	<0.001

Shown are the number of individuals (N) in each quartile of progression rates of the peak tricuspid regurgitant velocity as well as the number and percentage of all-cause deaths in each quartile, the median (IQR) of time to death in years, the unadjusted HR 95% CI, and P value for the risk of all-cause mortality by quartile (with quartile 1 as reference), and the adjusted HR, 95% CI, and P value for the risk of all-cause mortality by quartile (with quartile 1 as reference). Estimates are adjusted for baseline parameters including age, sex, presence of suboptimal image quality, body mass index, systolic and diastolic blood pressure, left ventricular ejection fraction, mitral regurgitation severity, tricuspid regurgitation severity, peak tricuspid regurgitant velocity, presence of right ventricular dilation, presence of right ventricular dysfunction, presence of a pacemaker or implantable cardioverter-defibrillator, and all clinical variables (diabetes mellitus, hypertension, hyperlipidemia, chronic kidney disease, smoking, acute myocardial infarction, chronic obstructive pulmonary disease, ischemic stroke, atrial fibrillation, and heart failure).

^aRepresents the P value for the unadjusted comparison across quartiles.

^bRepresents the P value for the adjusted comparison across quartiles.