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. Author manuscript; available in PMC: 2023 Oct 18.
Published in final edited form as: Eur J Med Chem. 2022 Nov 11;245(Pt 2):114916. doi: 10.1016/j.ejmech.2022.114916

Table 3.

Antitubercular activity, cytotoxicity and metabolic stability of compounds synthesized

graphic file with name nihms-1937709-t0019.jpg
Cmpd R X R1 R2 MIC90a (μg/mL) MtbH37Rv
58a H C H H >40
59a H N H H >40
60a 3-CH3 C H H >40
61a 4-OH C H H >40
62a 3-F C H H >40
63a 3-OH C H H >40
58b H N H CH3 >40
59b H C H CH3 >40
60b 3-CH3 C H CH3 >40
61b 4-OH C H CH3 >40
60c 3-CH3 C 4-OCH3 H >40
SM b 0.25
a

Minimum Inhibitory Concentration, determined by REMA method toward M. tuberculosis H37Rv;[69]

b

Streptomycin.