TABLE 2.
Renal function in neutropenic patients receiving AmBisome
| Dosage cohort (n) | Concn in serum (mean ± SD)
|
|||||
|---|---|---|---|---|---|---|
| Creatinine (mg/dl)
|
Potassium (meq/liter)
|
Magnesium (mmol/liter)
|
||||
| Baseline | End of therapy | Baseline | End of therapy | Baseline | End of therapy | |
| 1.0 mg/kg (8) | 0.98 ± 0.08 | 0.83 ± 0.07 | 3.8 ± 0.19 | 4.3 ± 0.13 | 0.81 ± 0.05 | 0.83 ± 0.03 |
| 2.5 mg/kg (8) | 0.93 ± 0.08 | 0.88 ± 0.07 | 4.2 ± 0.23 | 3.8 ± 0.15 | 0.84 ± 0.04 | 0.86 ± 0.06 |
| 5.0 mg/kg (12) | 0.95 ± 0.07 | 1.00 ± 0.13 | 3.9 ± 0.12 | 3.6 ± 0.18 | 0.75 ± 0.03 | 0.76 ± 0.03 |
| 7.5 mg/kg (8) | 1.01 ± 0.18 | 1.41 ± 0.23 | 4.2 ± 0.22 | 4.2 ± 0.32 | 0.68 ± 0.03 | 0.68 ± 0.04 |
| All patients (36) | 0.95 ± 0.04 | 1.03 ± 0.08 | 4.0 ± 0.09 | 3.9 ± 0.11 | 0.77 ± 0.02 | 0.78 ± 0.02 |