TABLE 3.
Hepatic function in neutropenic patients receiving AmBisome
| Dosage cohort (n) | Concna of:
|
|||||||
|---|---|---|---|---|---|---|---|---|
| AST (IU/liter)
|
ALT (IU/liter)
|
Alkaline phosphatase (IU/liter)
|
Total bilirubin (mg/dl)
|
|||||
| Baseline | End of therapy | Baseline | End of therapy | Baseline | End of therapy | Baseline | End of therapy | |
| 1.0 mg/kg (8) | 27 ± 11.6 | 14 ± 1.3 | 27.0 ± 10.9 | 19.8 ± 6.0 | 55.3 ± 3.2 | 89.6 ± 8.9‡ | 0.68 ± 0.16 | 0.73 ± 0.08 |
| 2.5 mg/kg (8) | 19.1 ± 4.6 | 28 ± 10.9 | 20.9 ± 5.0 | 43.6 ± 17.6* | 114.3 ± 26 | 182.1 ± 75.1 | 1.1 ± 0.19 | 1.9 ± 0.78* |
| 5.0 mg/kg (12) | 45.5 ± 10.8 | 44.4 ± 17.0 | 53.8 ± 13.7 | 47.0 ± 16.4 | 108.1 ± 8.5 | 146.6 ± 21.8‡ | 0.81 ± 0.13 | 1.00 ± 0.20 |
| 7.5 mg/kg (8) | 40.4 ± 9.4 | 40.3 ± 7.6 | 45.3 ± 8.1 | 45.9 ± 14.8 | 138.3 ± 25.7 | 164.4 ± 25.2 | 1.21 ± 0.18 | 5.39 ± 3.27† |
| All patients (36) | 34.4 ± 5.1 | 33.1 ± 6.5 | 38.6 ± 5.9 | 39.9 ± 7.5 | 104.4 ± 9.5 | 145.8 ± 19‡ | 0.94 ± 0.09 | 2.11 ± 0.77‡ |
a
Expressed as mean ± SD. *, P ≤ 0.05; †, P ≤ 0.01; ‡, P ≤ 0.001.