TABLE 5.
Pharmacokinetic variables in neutropenic patients receiving AmBisome
| Parameter (unit) | Value (mean ± SD) for dosage cohort
|
|||||||
|---|---|---|---|---|---|---|---|---|
| 1.0 mg/kg
|
2.5 mg/kg
|
5.0 mg/kg
|
7.5 mg/kg
|
|||||
| Day 1 | Last day | Day 1 | Last day | Day 1 | Last day | Day 1 | Last day | |
| AUC0–24 (μg/ml · h) | 27 ± 14 | 60 ± 20 | 65 ± 33 | 197 ± 183 | 269 ± 96 | 555 ± 311 | 476 ± 371 | 382 ± 148 |
| AUC0–∞ (μg/ml · h) | 32 ± 15 | 66 ± 21 | 71 ± 36 | 213 ± 196 | 294 ± 102 | 621 ± 371 | 534 ± 429 | 417 ± 155 |
| t1/2 (h) | 10.7 ± 6.4 | 7.0 ± 2.1 | 8.1 ± 2.3 | 6.3 ± 2.0 | 6.4 ± 2.1 | 6.8 ± 2.1 | 8.5 ± 3.9 | 6.9 ± 0.9 |
| V (liters/kg) | 0.58 ± 0.40 | 0.16 ± 0.04 | 0.69 ± 0.85 | 0.18 ± 0.13 | 0.22 ± 0.17 | 0.11 ± 0.08 | 0.26 ± 0.15 | 0.20 ± 0.07 |
| Vss (liters/kg) | 0.44 ± 0.27 | 0.14 ± 0.05 | 0.40 ± 0.37 | 0.16 ± 0.09 | 0.16 ± 0.10 | 0.10 ± 0.07 | 0.18 ± 0.10 | 0.17 ± 0.05 |
| CL (ml/h/kg) | 39 ± 22 | 17 ± 6 | 51 ± 44 | 22 ± 15 | 21 ± 14 | 11 ± 6 | 25 ± 22 | 20 ± 7 |