Table 1.

Reduction in each nerve parameter sorted by surgery and refractive power

Parameter	Low-moderate myopic SMILE (%)	High myopic SMILE (%)	P valuea	Low-moderate myopic LASIK (%)	High myopic LASIK (%)	P valueb	P valuec	P valued
1 mo
CNFD	48.1 ± 10.0	55.4 ± 11.5	.640	85.4 ± 5.4	81.6 ± 9.6	.744	.001*	.177
CNBD	48.1 ± 12.2	72.6 ± 9.6	.128	94.4 ± 2.4	91.4 ± 8.6	.635	<.001*	.246
CNFL	34.7 ± 5.2	46.9 ± 8.4	.241	61.9 ± 4.0	64.7 ± 4.4	.732	<.001*	.194
CTBD	39.1 ± 11.5	56.4 ± 7.2	.208	57.8 ± 5.2	74.6 ± 8.4	.132	.100	.156
CNFA	20.9 ± 4.9	48.6 ± 6.2	.003*	39.6 ± 5.1	48.4 ± 8.6	.422	.023*	.989
CNFW	−3.5 ± 2.7	−8.5 ± 4.2	.346	−16.2 ± 2.3	−31.4 ± 7.9	.018*	.002*	.014*
CFracDim	3.3 ± 0.4	6.8 ± 1.6	.049*	7.3 ± 1.0	7.5 ± 1.0	.906	.010*	.777
3 mo
CNFD	36.3 ± 17.2	22.4 ± 13.0	.540	75.5 ± 5.7	86.8 ± 6.6	.453	.010*	.021*
CNBD	14.7 ± 49.9	12.4 ± 23.3	.970	84.0 ± 5.4	100	.259	.043*	.144
CNFL	35.3 ± 10.6	30.7 ± 8.1	.741	62.7 ± 4.7	75.0 ± 5.5	.325	.004*	.015*
CTBD	25.3 ± 23.9	36.8 ± 14.8	.697	70.1 ± 5.3	67.1 ± 17.1	.840	.012*	.057
CNFA	20.0 ± 13.8	33.1 ± 9.2	.455	47.9 ± 4.7	64.6 ± 9.5	.193	.011*	.078
CNFW	−2.7 ± 5.0	1.5 ± 1.9	.471	−7.5 ± 1.7	−27.8 ± 9.3	.001*	.259	.024*
CFracDim	5.2 ± 1.6	32.0 ± 17.6	.127	9.4 ± 1.2	12.9 ± 1.8	.263	.037*	.261
6 mo
CNFD	48.9 ± 7.4	46.9 ± 7.4	.887	71.5 ± 5.3	90.8 ± 9.2	.192	.001*	.015*
CNBD	51.3 ± 11.0	57.3 ± 17.0	.760	78.8 ± 5.7	88.1 ± 11.9	.557	.043*	.045*
CNFL	41.2 ± 5.2	41.3 ± 8.3	.995	54.3 ± 3.1	66.7 ± 8.9	.166	.002*	.010*
CTBD	38.2 ± 16.1	49.5 ± 10.5	.614	64.8 ± 5.4	42.7 ± 21.9	.177	.015*	.270
CNFA	32.7 ± 6.6	36.2 ± 6.1	.723	38.0 ± 4.0	48.8 ± 14.8	.354	.021*	.078
CNFW	−1.1 ± 2.2	−2.8 ± 2.5	.620	−28.5 ± 6.8	−9.3 ± 2.3	.007*	.022*	.022*
CFracDim	5.6 ± 0.9	5.1 ± 1.6	.774	7.1 ± 0.7	10.8 ± 1.9	.064	.013*	.512
12 mo
CNFD	29.4 ± 7.6	32.3 ± 6.4	.781	62.2 ± 4.6	80.7 ± 19.3	.189	<.001*	.007*
CNBD	41.8 ± 17.0	49.6 ± 8.9	.658	72.4 ± 4.1	88.5 ± 11.5	.170	<.001*	.261
CNFL	29.4 ± 4.5	34.5 ± 5.7	.503	46.8 ± 3.3	54.3 ± 7.1	.421	.001*	.026*
CTBD	41.5 ± 18.9	39.6 ± 8.3	.912	49.4 ± 5.2	71.6 ± 14.2	.139	.585	.126
CNFA	36.0 ± 9.9	27.3 ± 5.3	.403	29.7 ± 4.1	45.4 ± 13.0	.190	.488	.026*
CNFW	1.7 ± 2.8	−1.5 ± 1.2	.233	−5.9 ± 1.6	−30.2 ± 14.3	.001*	.017*	.004*
CFracDim	4.3 ± 1.0	2.9 ± 0.6	.248	6.2 ± 0.8	7.3 ± 0.7	.620	.006*	.007*

CFracDim = corneal nerve fiber fractal dimension; CNBD = corneal nerve branch density; CNFA = corneal nerve fiber area; CNFD = corneal nerve fiber density; CNFL = corneal nerve fiber length; CNFW = corneal nerve fiber width; CTBD = corneal nerve fiber total branch density

^*Statistically significant

^aP values comparing low-moderate myopic SMILE vs high myopic SMILE

^bP values comparing low-moderate myopic LASIK vs high myopic LASIK

^cP values comparing low-moderate myopic SMILE vs low-moderate myopic LASIK

^dP values comparing high myopic SMILE vs high myopic LASIK