TABLE 1.

Effects of different dosing regimens of BMS 181184 on pulmonary tissue injury, lung weight, pulmonary tissue burden, and detection of A. fumigatus in cultures of BAL fluid^a

Dosing regimen (no. of rabbits)b	Lesion score (lesions/lobe)	Lung wt (g)	Fungal burden [log (CFU/g)]	No. (%) of rabbits with culture-positive BAL fluid
Untreated controls (9)	4.33 ± 0.50	34.12 ± 4.00	1.87 ± 0.19	7 (78)
AmB, 1 mg/kg (8)	0.25 ± 0.25 c	11.27 ± 0.42 c	0.03 ± 0.03 c	0 (0) e
BMS, 50 mg/kg QD (6)	0.83 ± 0.47	13.17 ± 1.70	0.83 ± 0.18 a,d,f	1 (17) a
BMS, 17 mg/kg TID (5)	0.60 ± 0.40	11.32 ± 0.58 b	0.51 ± 0.16 c	2 (40)
BMS, 150 mg/kg QD (6)	0.33 ± 0.21 b	13.02 ± 0.64	0.20 ± 0.11 c	0 (0) b
BMS, 50 mg/kg TID (6)	0.33 ± 0.33 b	12.00 ± 1.32 b	0.25 ± 0.12 c	0 (0) b

^aAll values are means ± SEM. Statistical significance: a, P < 0.05 versus untreated controls; b, P < 0.01 versus untreated controls; c, P < 0.001 versus untreated controls; d, P < 0.01 versus AmB-treated rabbits; e, P < 0.005 versus AmB-treated rabbits; f, P < 0.05 versus rabbits treated at 50 mg/kg TID and 150 mg/kg QD. 

^bBMS, BMS 181184.