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. 2023 Jun 1;108(11):2812–2820. doi: 10.1210/clinem/dgad309

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Published by Oxford University Press on behalf of the Endocrine Society 2023.

This work is written by (a) US Government employee(s) and is in the public domain in the US.

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Figure 2. — Coefficient of variation for ACTH is restored with remission from Cushing’s disease. (A) Preoperative plasma ACTH measurements obtained on multiple (at least 3) days during the workup for Cushing's disease in 253 patients. The open circles show the Am ACTH values and the closed circles show the midnight values for individual days. Each column represents a patient included in this study. (B) Conceptual representation of the intra-patient variability in plasma ACTH levels and its relationship to the diurnal ACTH changes. (C) The median (bar) coefficient of variation and interquartile range (range bars) of preoperative plasma ACTH and postoperative 6:00 Am and 12:00 Am for patients in remission and nonremission.