Table 2.
ACTH variation in Cushing's diseasea
| Postoperative | |||||
|---|---|---|---|---|---|
| Preoperative n = 54 | Nonremissionn = 50 | P-value | Remissiona n = 223 | P-value | |
| Intra-patient ACTH variability | |||||
| median CV | |||||
| AM (4 Am–8 Am) | 19.8 (IQR: 12.5–27.5) |
24.4 (IQR: 16.1–32.8) |
0.962 |
36.3
(IQR: 10.9–54.7) |
.02 |
| PM (10 Pm–2 Am) | 24.0 (IQR: 9.6–31.8) |
17.0 (IQR: 6.2–37.2) |
0.676 |
44.2
(IQR: 12.6–71.8) |
<.001 |
| Inter-patient ACTH variability | |||||
| mean ACTH | |||||
| AM (4 Am–8 Am) | 42.4 ± 27.0 | 42.2 ± 31.4 | 0.7403 | 8.6 ± 8.9 | <.0001 |
| PM (10 Pm–2 Am) | 40.1 ± 29.9 | 36.0 ± 31.1 | 0.7491 | 11.2 ± 10.0 | <.0001 |
Abbreviations: CV, coefficient of variation; IQR, interquartile range.
Remission defined as ≥1 postoperative serum cortisol <5 ug/dL within 10 days after surgery.
P-values are from one-way ANOVA using the Sidak method for unequal variance, showing the significance or lack thereof compared to the preoperative CV for the corresponding time point. Statistically significant findings in boldface font.