Table 3.
Variables predicting nonremissiona
| OR | 95% CI | P-value | Adj OR | Adj 95% CI | Adj P-value | |
|---|---|---|---|---|---|---|
| Demographics | ||||||
| Age | 0.99 | 0.98–1.01 | .1587 | — | — | — |
| Female | 0.96 | 0.58–1.60 | .8687 | — | — | — |
| White | 0.69 | 0.39–1.24 | .2037 | — | — | — |
| ACTH variables | ||||||
| POD 1 Am | ||||||
| ACTH | 1.08 | 1.05–1.11 | <.001 | 1.10 | 1.06–1.14 | <.001 |
| Ratio to Bsl | 1.02 | 1.01–1.02 | <.001 | 1.02 | 1.01–1.02 | .001 |
| Difference from Bsl | 1.02 | 1.00–1.03 | .027 | 1.03 | 1.00–1.03 | .041 |
| POD 0 Pm | ||||||
| ACTH | 1.04 | 1.02–1.06 | .001 | 1.05 | 1.02–1.07 | <.001 |
| Ratio to Bsl | 1.01 | 1.00–1.01 | .004 | 1.01 | 1.00–1.02 | .007 |
| Difference from Bsl | 1.02 | 1.00–1.03 | .013 | 1.02 | 1.00–1.04 | .018 |
| POD 1 Pm | ||||||
| ACTH | 1.12 | 1.07–1.17 | <.001 | 1.16 | 1.09–1.23 | <.001 |
| Ratio to Bsl | 1.03 | 1.02–1.05 | <.001 | 1.03 | 1.02–1.05 | <.001 |
| Difference from Bsl | 1.03 | 1.01–1.05 | .014 | 1.02 | 1.00–1.04 | .044 |
| POD 2 Pm | ||||||
| ACTH | 1.11 | 1.05–1.16 | <.001 | 1.15 | 1.07–1.23 | <.001 |
| Ratio to Bsl | 30.20 | 5.81–157.12 | <.001 | 37.60 | 5.85–241.72 | <.001 |
| Difference from Bsl | 1.02 | 1.00–1.05 | .035 | 1.02 | 1.00–1.05 | .036 |
| POD 3 Pm | ||||||
| ACTH | 1.12 | 1.04–1.21 | .002 | 1.11 | 1.03–1.20 | .005 |
| Ratio to Bsl | 87.20 | 5.04–1507.29 | .002 | 149.66 | 4.03–5560.87 | .007 |
| Difference from Bsl | 1.07 | 1.01–1.13 | .016 | 1.10 | 1.01–1.19 | .031 |
Abbreviations: Bsl, baseline, preoperative ACTH for the corresponding time point; CI, confidence interval; OR, odds ratio; POD, postoperative day.
Remission defined as ≥ 1 post-operative serum cortisol < 5ug/dL within 10 days after surgery.
P-values are from multivariable logistic regression adjusting for age, female, and White race, with nonremission as the dependent variable. Statistically significant findings in boldface font.