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. Author manuscript; available in PMC: 2023 Oct 18.
Published in final edited form as: Nat Rev Cardiol. 2022 May 6;19(11):723–736. doi: 10.1038/s41569-022-00703-y

Fig. 1 |. Structure and function of DNM1L in mitochondrial fission.

Fig. 1 |

a | Cytosolic dynamin-1-like protein (DNML1; also known as dynamin-related protein 1 (DRP1) monomers are recruited to the outer mitochondrial membrane by the adaptor proteins mitochondrial fission 1 (FIS1), mitochondrial dynamics protein 49 (MID49) or MID51 and mitochondrial fission factor (MFF), which facilitates the formation of helical ring DNML1 oligomers. GTP hydrolysis by DNML1 stimulates OMM constriction and subsequent scission. b | Several post-translational modifications within the variable region and GTPase effector domain (GED) of DNML1 regulate fission. O-GlcNAcylation, O-linked-N-acetylglucosaminylation.