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. Author manuscript; available in PMC: 2023 Oct 18.
Published in final edited form as: Nat Rev Cardiol. 2022 May 6;19(11):723–736. doi: 10.1038/s41569-022-00703-y

Fig. 2 |. Interorganelle contacts promote mitochondrial fission.

Fig. 2 |

Mitochondria–endoplasmic reticulum (ER) association membranes, in conjunction with polymerized actin, promote DNML1 recruitment and outer mitochondrial membrane OMM constriction. Uptake of calcium (Ca2+) into the mitochondria stimulates inner membrane constriction. phosphatidylinositol 4-phosphate (PI4P) is also critical for the execution of mitochondrial fission and can be transferred to the OMM through lysosomes or trans-Golgi-derived vesicles.