. Author manuscript; available in PMC: 2023 Oct 18.

Published in final edited form as: Nat Rev Cardiol. 2022 May 6;19(11):723–736. doi: 10.1038/s41569-022-00703-y

Table 2 |.

Genetic mouse models of Dnm1l knockout in non-cardiac tissues

Genetic model	Outcome		Refs
Genetic model	Basal characterization	Effects of pathological stress	Refs
Skeletal muscle-specific knockout	Reduced body growth, muscle fibre number and size. Defects in respiratory complex assembly and function. Lethality by postnatal day 30.	NR	⁸⁰
Tamoxifen-inducible, skeletal muscle-specific knockout	Reduced body weight at 50 days post-tamoxifen. Reduced muscle mass and fibre size 70–180 days post-tamoxifen. Mitochondrial dysfunction and impaired mitophagy.	NR	⁸⁰
T cell-specific knockout	Impaired migration and expansion of developing thymocytes.	Accelerated tumour growth.	¹²¹
Myeloid/macrophage-specific knockout	Impaired macrophage-mediated uptake of apoptotic cells (i.e. efferocytosis).	Accelerated plaque necrosis in the Ldlr^−/− model of atherosclerosis. Protection against vascular remodelling and fibrosis following arterial injury. Reduced macrophage activation and cell proliferation in injured arteries.	^126,153
Liver-specific knockout	Reduced liver and white adipose tissue weights. Reduced serum triacylglycerol and total cholesterol levels.	Protection from high-fat diet-induced obesity.	^12,152
Endothelial cell-specific knockout	NR	Protection against TNF-driven endothelial leukocyte adhesion.	¹⁵⁵

DNM1L, dynamin-1-like protein (also known as dynamin-related protein 1 (DRP1)); LDLR, low-density lipoprotein receptor; NR, not reported; TNF, tumour necrosis factor.