FIG. 2.

Histology from original right occipital (A) lesion and the second tumor recurrence 27 months later (B). Histologically, the initial lesion was consistent with a grade 3 anaplastic astrocytoma using World Health Organization (WHO) 2016 criteria, with GFAP expression and TP53 overexpression by neoplastic cells. The patient’s second recurrent lesion (B) histologically and by molecular evaluation met criteria for the newly recognized entity diffuse hemispheric glioma with GFAP and increased TP53 overexpression, increased mitotic figures, areas of necrosis (*) and vascular proliferation (#). HPF = high-power field.