TABLE 3.

Mean serum creatinine, lactate dehydrogenase, alanine transaminase, aspartate transaminase, and alkaline phosphatase levels in noninfected mice and mice infected with C. albicans before and during pentoxifylline administration

Mice	Day	Time (min)	Mean level ofc:
			Creatinine (mg/dl)	LD (U/ml)	ALT (U/ml)	AST (U/ml)	AP (U/ml)
Untreated, noninfected mice	N/Aa	N/A	0.2	812	54	330	222
Noninfected	0	−20d	0.2	1,530	64	517	249
		5	0.4	1,022	49	192	260
		15	0.3	891	49	190	276
		30	0.3	1,205	61	297	266
		60	0.1	1,740	71	370	275
Noninfected	1	−20	0.1	1,592	86	631	248
		5	0.3	1,105	40	358	244
		15	0.3	1,360	36	447	255
		30	0.2	1,262	42	393	252
		60	0.2	840	54	319	255
Noninfected	2	−20	0.2	1,762	68	405	251
		5	0.3	1,483	44	364	234
		15	0.2	903	46	232	254
		30	0.2	833	49	225	231
		60	0.2	904	68	441	219
Infected	0	−20	0.2	2,359	52	324	223
		5	0.1	1,659	49	370	190
		15	0.2	1,354	54	402	240
		30	0.2	1,455	48	334	229
		60	0.1	1,510	65	484	209
Infected	1	−20	1.2	>600b	296	>1,000b	112
		5	1.1	>600b	342	>1,000b	128
		15	1.2	>600b	371	>1,000b	100
		30	1.2	9,564	331	5,243	103
		60	1.1	4,835	161	3,089	97
		90	1.1	>600b	203	>1,000b	>1,000b

^aN/A, not applicable. 

^bInsufficient sample to further quantify value. 

^cLD, lactate dehydrogenase; ALT, alanine transaminase; AST, aspartate transaminase; AP, alkaline phosphatase. 

^dLevels were measured 20 min before drug administration.