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The pathogenesis of AS. ER stress triggered by the HLA-B27 gene may be the trigger for AS, and the T cell cross-reactivity triggered by the formed complex may also be one of the triggers. The IL-23/IL-17 pathway in the body plays an important role in the overall pathogenesis and is an important player in leading to inflammation and cartilage damage. MIF, macrophage migration inhibitor. TCR, T cell receptor.
