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. 2023 Oct 4;14:1267091. doi: 10.3389/fimmu.2023.1267091

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Copyright © 2023 Xiang, Zhang, Jiang, Su and Shi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The pathogenesis of IBDs. The occurrence of IBD is often accompanied by immune disorders, intestinal flora disorders, and metabolic disorders, which are related to the imbalance regulation between inflammatory cells, immune cells, and intestinal groups. The damage of this intestinal epithelial cell triggers a cascading response by the immune system, and the various cytokines produced can trigger the destruction of the intestinal mucosal barrier, leading to the appearance of intestinal inflammation.CLT, Cytotoxic lymphoid T cells. CXC, chemotaxis.