Table 2. Final (physical) time for model steady states in ODE benchmarks.

Model:	Multistate	Multisite2	Egfr_net	BCR	Fceri_gamma2
	20 s	2 s	10 s	20,000 s	150 s

For each model, we determined the time at which it had (approximately) reached a steady state. These times were used for the ODE benchmarks in Fig 3 and Fig A in S1 Text. Unlike the other models, BCR exhibits a limit cycle. Here, rather than simulating until an (approximate) steady state had been reached, we simulated it for 20,000 time units (permitting it to complete 3 pulse events, Fig G in S1 Text).