TABLE 1.

Effect of chemical modification on the lipophilicities of antimalarial agents as measured by octanol:water partitioning at pH 5.0 and pH 7.4

Drug	Lipophilicity (log D)
	pH 5.0	pH 7.4
Amodiaquine	−1.16	0.93
Amopyroquine	−1.15	0.68
5′-C1PAQ	1.20	1.18
Tebuquine	0.99	1.08
Cycloquine	−1.35	0.98
Bis-pyroquine	−1.27	0.71
Pyronaridine	−0.88	0.34