. 1998 Sep;42(9):2410–2416. doi: 10.1128/aac.42.9.2410

TABLE 2.

Distribution of radioactivity in tissue or blood over 48 h following administration of single i.p. doses of [³H]amodiaquine, [³H]5′-ClPAQ, and [³H]cycloquine to CD1 mice

Compartment	Drug^a	% Dose/compartment at the following times^b:
Compartment	Drug^a	3 h	6 h	18 h	24 h	48 h
Liver	AQ	4.3 ± 1.2	3.5 ± 1.0	9.2 ± 8.5	2.9 ± 1.1	0.9 ± 0.2
	5′-ClPAQ	13.8 ± 2.7**	13.6 ± 2.5***	17.8 ± 1.6	14.8 ± 3.7***	10.7 ± 1.6***
	CYC	12.9 ± 5.9**	12.4 ± 2.0***	10.8 ± 1.8	10.4 ± 2.2***	13.3 ± 1.3***^,††
Kidney	AQ	1.5 ± 0.1	1.3 ± 0.4	0.6 ± 0.1	0.5 ± 0.2	0.7 ± 1.3
	5′-ClPAQ	3.8 ± 1.1**	4.5 ± 1.2***	9.0 ± 0.6***	4.4 ± 1.2***	6.0 ± 1.1***
	CYC	2.2 ± 0.9^†	1.8 ± 0.2^†††	1.7 ± 0.1***^,†††	1.7 ± 0.5*^,†††	2.3 ± 0.3*^,†††
Lung	AQ	0.7 ± 0.2	0.5 ± 0.1	0.3 ± 0.1	0.2 ± 0.1	0.1 ± 0.01
	5′-ClPAQ	1.4 ± 0.4	2.1 ± 0.7***	4.5 ± 0.6***	2.7 ± 0.9***	2.1 ± 0.4***
	CYC	1.3 ± 0.7	1.0 ± 0.2*^,†	0.4 ± 0.1^†††	0.4 ± 0.3**^,†††	0.8 ± 0.2***^,†††
Spleen	AQ	0.4 ± 0.1	0.4 ± 0.1	0.3 ± 0.1	0.05 ± 0.1	0.01 ± 0.05
	5′-ClPAQ	0.9 ± 0.2*	1.9 ± 0.5***	2.3 ± 0.2***	2.7 ± 0.7***	1.3 ± 0.2***
	CYC	0.6 ± 0.3^†	0.6 ± 0.1^†††	0.4 ± 0.1*^,†††	0.6 ± 0.1^†††	0.7 ± 0.1***^,†††
Gastrointestinal tract	AQ	1.4 ± 1.9	18.9 ± 4.5	24.3 ± 13.6	21.7 ± 9.6	3.4 ± 2.7
	5′-ClPAQ	19.6 ± 4.5**	18.3 ± 3.4	34.1 ± 3.3	19.4 ± 4.7	10.5 ± 1.2
	CYC	22.4 ± 7.6***	17.3 ± 0.9	18.7 ± 4.8	21.2 ± 3.3	5.9 ± 3.8
Blood	AQ	0.4 ± 0.5	1.3 ± 0.2	0.2 ± 0.2	0.7 ± 0.1	0.3 ± 0.01
	5′-ClPAQ	0.3 ± 0.1	5.2 ± 3.8	1.0 ± 0.1	1.0 ± 0.05	0.4 ± 0.05
	CYC	0.3 ± 0.1	0.4 ± 0.0	0.3 ± 0.0	0.4 ± 0.1	0.3 ± 0.1

The drug doses are given in the text. AQ, [³H]amodiaquine; 5′-ClPAQ, [³H]5′-ClPAQ; CYC, [³H]cycloquine.

Data are means ± SDs (n = four mice per time point). *, P < 0.05; **, P < 0.01; ***, P < 0.001 compared with amodiaquine; †, P < 0.05; ††, P < 0.01; †††, P < 0.001 for cycloquine compared with 5′-ClPAQ.