TABLE 3.

Excretion of radioactivity in urine and feces over 48 h following administration of a single i.p. dose of [³H]amodiaquine, [³H]5′-ClPAQ, and [³H]cycloquine to male CD1 mice and excretion into bile following intravenous administration.

Compartment	Druga	% Dose/sample at the following timesb:
		3 h	6 h	18 h	24 h	48 h
Feces	AQ	6.3 ± 0.6	6.5 ± 3.8	14.9 ± 7.0	22.7 ± 10.5	NMc
	5′-ClPAQ	0.1 ± 0.2	0.1 ± 0.1**	2.4 ± 1.0***	2.1 ± 0.1***	3.4 ± 0.7***
	CYC	NM	0.2 ± 0.2**	4.5 ± 0.5**	3.3 ± 1.4**	NM
Urine	AQ	7.8 ± 0.1	8.4 ± 4.2	14.4 ± 3.7	22.7 ± 6.0	NM
	5′-ClPAQ	3.6 ± 1.9	2.3 ± 1.3**	4.3 ± 4.1***	4.6 ± 1.4***	2.7 ± 1.3***
	CYC	NM	0.1 ± 0.0***	0.2 ± 0.1***	0.2 ± 0.1***	NM
Bile	AQ	28.5 ± 6.7d
	5′-ClPAQ	3.0 ± 0.9
	CYC	0.6 ± 0.2

^aThe drug doses are given in the text. AQ, [³H]amodiaquine; 5′-ClPAQ, [³H]5′-ClPAQ; CYC, [³H]cycloquine. 

^bValues are means ± SDs (n = four mice per time point). **, P < 0.01; ***, P < 0.001 compared with amodiaquine. 

^cNM, not measured. 

^dData taken from reference 19.