TABLE 2.
Pharmacokinetic parameters for meropenem
| Patient no. | Cmax (μg/ml)a | CLtot (ml/min) | CLHF (ml/min) | kel (h−1) | V (liters) | t1/2 (h) | AUC (mg/liter · h) |
|---|---|---|---|---|---|---|---|
| 1 | 30.9 | 128.7 | 59.3 | 0.27 | 28.9 | 2.59 | 129.5 |
| 2 | 27.5 | 145.4 | 36.3 | 0.29 | 30.1 | 2.39 | 114.7 |
| 3 | 32.1 | 162.8 | 51.4 | 0.40 | 24.5 | 1.74 | 102.4 |
| 4 | 24.8 | 115.5 | 57.9 | 0.23 | 30.1 | 3.00 | 144.3 |
| 5 | 28.8 | 163.1 | 41.8 | 0.35 | 28.2 | 2.00 | 102.2 |
| 6 | 27.3 | 161.5 | 41.5 | 0.31 | 31.0 | 2.22 | 103.2 |
| 7 | 25.0 | 163.6 | 44.3 | 0.29 | 33.9 | 2.39 | 101.9 |
| 8 | 25.1 | 129.8 | 57.1 | 0.23 | 33.9 | 2.46 | 118.0 |
| 9 | 31.4 | 122.7 | 57.4 | 0.25 | 29.3 | 2.76 | 135.9 |
| Mean ± SD | 28.1 ± 2.5 | 143.7 ± 18.6 | 49.7 ± 8.3 | 0.31 ± 0.05 | 29.5 ± 2.7 | 2.33 ± 0.38 | 118.0 ± 15.8 |
a
Cmax, peak concentration of meropenem in plasma.