Table 1.
Participant characteristics by group (Mean ± SEM).
| AMC (n = 14) | BSO+ERT (n = 15) | BSO (n = 16) | SM (n = 17) | |
|---|---|---|---|---|
| Urinary estrone-3-glucuronide (ng/ml) | 36.93 ± 4.80 | 28.67 ± 4.76 | 16.83 ± 2.18a,b | 18.22 ± 2.55c,d |
| Urinary pregnanediol glucuronide (mIU/ml) | 2.45 ± 0.74 | 2.64 ± 0.92 | 0.90 ± 0.21 | 0.58 ± 0.09 |
| Current Age (years) | 43.64 ± 1.26 | 43.13 ± 1.09 | 46.00 ± 1.31 | 55.94 ± 0.81c-e |
| Education (years) | 18.29 ± 0.65 | 18.20 ± 0.63 | 17.78 ± 0.61 | 16.29 ± 0.59 |
| BMI (kg/m2) | 23.56 ± 1.26 | 27.19 ± 1.18 | 25.21 ± 1.14 | 26.25 ± 1.10 |
| Age at menopause (years) | -- | 39.87 ± 1.00 | 41.50 ± 0.97 | 51.35 ± 0.73d,e |
| Time since menopause (years) | -- | 3.59 ± 0.93 | 5.10 ± 0.93 | 4.55 ± 0.87 |
| PSQI | 4.05 ± 1.03 | 6.27 ± 0.84 | 6.64 ± 0.87 | 6.00 ± 0.94 |
| CESD | 10.79 ± 2.05 | 9.27 ± 1.98 | 8.81 ± 1.92 | 6.53 ± 1.86 |
| PSS | 15.64 ± 1.75 | 14.33 ± 1.69 | 13.25 ± 1.64 | 11.59 ± 1.59 |
| Scanned participants | n=8 | n =10 | n =12 | n =14 |
| eTIV cm3 | 14865.71 ± 507.08 | 13574.66 ± 453.55 | 15194.79 ± 414.03 | 14346.18 ± 383.32 |
| Scan image quality rating (0-3) | 2.60 ± 0.18 | 2.60 ± 0.17 | 2.71 ± 0.15 | 2.32 ± 0.14 |
AMC, age-matched premenopausal controls; BMI, body mass index; BSO, bilateral salpingo-oophorectomy; CESD, Center for Epidemiological Studies Depression Scale; eTIV, estimated total intracranial volume; ERT, estradiol-based hormone replacement therapy; PSQI, Pittsburgh Sleep Quality Index; PSS, Perceived Stress Scale; SM, spontaneous menopause. aBSO vs AMC, bBSO vs BSO+ERT; cSM vs AMC, dSM vs BSO+ERT; eSM vs BSO, p < .05.
"-" denotes not applicable.