TABLE 1.
Antibiotic MIC and MBC determinations for S. aureus ATCC 29213
| Antibiotic | % Protein bound | MIC (μg/ml) in:
|
MBC (μg/ml) in:
|
||
|---|---|---|---|---|---|
| MHB | MHBS | MHB | MHBS | ||
| Gentamicin | 5–10 | 0.5 | 0.5 | 1 | 1 |
| Amoxicillin/clavulanateb | 17/20 | 0.5/0.25 | 0.5/0.25 | 2/1 | 2/1 |
| Imipenem | 20 | 0.015 | 0.03 | 0.03 | 0.06 |
| Vancomycin | 30 | 1 | 1 | 4 | 4 |
| Cefotaxime | 35 | 2 | 4 | 4 | 4 |
| Cefuroxime | 35 | 2 | 2 | 4 | 4 |
| Ciprofloxacin | 40 | 0.5 | 0.5 | 1 | 1 |
| Erythromycin | 60 | 0.5 | 0.25 | 8 | 8 |
| Rifampin | 75 | 0.015 | 0.03 | 0.125 | 0.25 |
| Cefazolin | 80 | 0.5 | 2a | 1 | 4a |
| Ceftriaxone | 83–96 | 4 | 16a | 8 | 32a |
| LY333328 | >80 (rat) | 0.5 | 4a | 0.5 | 4a |
| Teicoplanin | 90 | 0.5 | 2a | 0.5 | 2a |
| Clindamycin | 94 | 0.125 | 1a | 2 | 16a |
| Cloxacillin | 94 | 0.25 | 2a | 0.5 | 4a |
a
This is a value that is significantly (P ≤ 0.05) larger in MHBS.
b
Values for each drug in this combination are given.