Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Sep 13;622(7983):637–645. doi: 10.1038/s41586-023-06510-w

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 3 — a, Visualization of the LCA of all non-singleton clusters as a Sankey plot produced by Pavian. Only the largest 13 taxonomical nodes per rank are shown. b, The distribution of selected GO terms across the human lineage of the LCA based on the analysis of human protein-containing clusters (abundance is normalized per GO category). c, Three example structures from the human clusters that are conserved across humans and bacteria, among the eukaryote GO-annotated clusters. A histone protein with a nucleus GO annotation, which was found to be conserved at the cellular organism level and supports the previously reported evolutionary connection between eukaryotic and bacterial histones (left)²⁶. The human innate immunity genes BPI (middle) and AIM2 (right) encode structurally similar proteins in bacterial species, highlighting the potential for cross-kingdom sharing of immunity-related proteins. Acido. bacterium, Acidobacteria bacterium; Actino. bacterium, Actinomycetia bacterium; ‘Ca. Bathyarchaeota archaeon’, ‘Candidatus Bathyarchaeota archaeon’; D. bacterium, Deltaproteobacteria bacterium; H. pylori, Helicobacter pylori; memb., membrane; P. bacterium, Planctomycetes bacterium; R. irregularis, Rhizophagus irregularis; S. enterica, Salmonella enterica; T. cinerariifolium, Tanacetum cinerariifolium.