Extended Data Fig. 9. Putative functional annotation of NMPFs with potential novel structural folds.

Three example NMPFs (a-c) are shown. The produced AlphaFold 3D model (left), gene co-occurrence analysis (middle) and ecosystem distribution (right) are given. 3D models are coloured based on their per-residue structure confidence (pLDDT). The gene neighbourhood of each NMPF is presented in the form of an association network; with nodes representing gene products (the NMPFs and their adjacent genes that encode Pfam domains) and edges representing co-occurrence in the same sequencing scaffold. Pfam domains are further grouped using their associated COG functional categories as annotation. Finally, the NMPFs’ associated ecosystems are presented in pie charts. Ecosystems with a <1% presence in the NMPFs are summed into the category “Other ecosystems”.