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. 2023 Oct 11;622(7983):594–602. doi: 10.1038/s41586-023-06583-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a, UpSet plot showing the domain-level taxonomic distribution of novel protein clusters. The total size of each taxonomic category is represented through the horizontal bar chart on the left. The intersections among categories are represented by the chart at the bottom, with sizes of the intersections represented by the vertical bar chart at the top. b,c, We determined whether NMPFs were found on scaffolds from the GEM catalogue (b) and whether they were found on scaffolds from one or more cultivated species (c). d, The taxonomic rank of the lowest common ancestor (LCA) for 2,419 clusters found in at least 2 MAGs. e, The percentage of genes matching a cluster from MAGs assigned to different phyla. The asterisks indicate significant P values from a hypergeometric test. Green, clusters enriched in the phylum; red, clusters depleted from the phylum. The number of genes matching clusters is indicated in parenthesis next to the phylum name.