TABLE 2.

Effect of multidose AmBisome treatment with or without a single dose of Fungizone on survival of leukopenic mice^a and growth of C. albicans in the kidney

Treatmentb	Daily dose (mg/kg)	No. of doses	Log10 CFU/kidney in surviving mice on dayc:
			3	7
AmBisome	5	5	5.39 ± 0.45 (60)	4.57 ± 1.11 (30)
Fungizone + AmBisome	0.1 + 5	1 + 5	3.00 ± 0.17d (100)	2.06 ± 0.31d,e (100)
Fungizone	0.1	1	5.67 ± 0.12 (40)	6.38 ± 0.41 (40)

^aLeukopenic mice were inoculated i.v. at time zero with 3 × 10⁴ CFU of C. albicans; untreated mice died between 24 h and 8 days after C. albicans inoculation. 

^bAmBisome and Fungizone were administered i.v. at 20 h after C. albicans inoculations. In the combination treatment, both agents were administered separately, with the first dose of AmBisome being given directly after Fungizone. 

^cThe effect of treatment was determined at day 3 (n = 10) as well as day 7 (n = 10) after inoculation. The log₁₀ CFU/kidney at the start of treatment (day 0) was 4.34 ± 0.19. Each value represents the geometric mean ± the standard deviation. The numbers in parentheses indicate the percentages of surviving mice (see also the legend to Table 1). 

^dP ≤ 0.002 compared with the number of CFU at the start of treatment. 

^eP ≤ 0.002 compared with the number of CFU at day 3 after inoculation.