Table 2.

Age distribution and biochemical parameters in 44 children with infantile nephropathic cystinosis and 97 CKD controls

	INC			CKD
Repeated measurements	Estimated marginal mean (95% CI)	Min.–Max	N	Estimated marginal mean (95% CI)	Min.–Max	N	p-value
Mean age, years	9.94 (9.09–10.78)	2.28–17.90	9	9.13 (8.57–9.70)	2.09–17.93	221	0.121
Cohort 2–6 yrs	4.95 (4.28–5.63)	2.28–6.99	32	4.57 (4.11–5.02)	2.09–6.96	77	0.342
Cohort 7–12 yrs	9.82 (9.02–10.63)	7.33–12.82	29	10.02 (9.60–10.44)	7.00–12.99	100	0.649
Cohort 13–17 yrs	15.21 (14.54–15.88)	13.05–17.90	31	15.15 (14.65–15.65)	13.08–17.93	44	0.881
eGFR, mL/min per 1.73 m2	65.84 (59.70–71.98)	6.58–137.67	91	47.89 (44.08–51.70)	9.01–144.87	220	0.000
HCO3, mmol/L	22.84 (22.34–23.34)	16.7–29.20	74	22.86 (22.56–23.17)	16.70–30.00	213	0.946
Hemoglobin, g/dL	12.90 (12.52–13.28)	8.10–17.90	89	12.46 (12.28–12.65)	8.00–17.80	219	0.042
Sodium, mmol/L	139.86 (139.21–140.52)	132.00–151.00	90	140.41 (140.10–140.71)	133.00–149.00	219	0.136
Potassium, mmol/L	3.89 (3.78–3.99)	2.37–5.84	91	4.54 (4.47–4.61)	3.27–5.92	219	0.000
Calcium, mmol/L	2.28 (2.25–2.31)	1.84–2.55	79	2.37 (2.36–2.39)	1.90–2.97	208	0.000
Calcium, z-score	− 0.88 (− 1.12 to − 0.64)	− 4.74–1.40	79	− 0.08 (− 0.24–0.07)	− 4.95–4.87	208	0.000
Phosphate, mmol/L	1.32 (1.27–1.38)	0.67–2.39	83	1.46 (1.43–1.50)	0.92–2.11	208	0.000
Phosphate, z-score	− 1.10 (− 1.47 to − 0.73)	− 4.49–5.16	83	− 0.49 (− 0.66– − 0.33)	− 3.08–3.14	208	0.003
PTH, ng/L	106.61 (77.69–135.54)	4.10–623.40	81	97.35 (87.69–107.02)	5.10–607.92	196	0.548

N describes the number of valid measurements for respective parameter out of overall patient measurements, i.e., across all age subgroups. Repeated measurements per patient were evaluated in linear-mixed models