Table 4.

Sub-group analysis (Inclusion of only ARB as first-line therapy)

	ARB	BB	p-value
Before treatment
Z-Score annulus	1.32 ± 0.98	1.51 ± 1.36	0.588
Z-Score Sinus Valsalva	1.85 ± 0.94	2.66 ± 1.59	0.086
Z-Score sinotubular junction	0.88 ± 0.89	1.74 ± 1.06	< 0.01 (0.008)
At follow-up
Z-Score annulus	1.18 ± 0.94	2.10 ± 1.28	< 0.01 (0.006)
Z-Score Sinus Valsalva	1.62 ± 0.90	2.86 ± 1.50	< 0.01 (0.009)
Z-Score sinotubular junction	0.72 ± 0.86	2.16 ± 1.31	< 0.01 (< 0.001)
Difference*
Z-Score annulus	− 0.14 ± 0.89	0.59 ± 0.88	< 0.05 (0.014)
Z-Score Sinus Valsalva	− 0.23 ± 0.40	0.20 ± 0.33	< 0.01 (< 0.001)
Z-Score sinotubular junction	− 0.17 ± 0.74	0.42 ± 1.01	< 0.05 (0.030)

*between z-score values before therapy initiation and follow-up after therapy initiation

z-scores of the aortic annulus, Sinus Valsalva Aortae, and sinotubular junction before and after initiation of angiotensin receptor blocker (ARB) and beta blocker (BB) therapy

ARB Angiotensin-receptor-blocker (n = 66), BB  Betablocker (n = 14)

Age in years (average): ARB = 7.57 / BB = 9.98 / p = 0.085