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. 2023 Apr 25;112(11):1587–1599. doi: 10.1007/s00392-023-02200-9

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Adjusted* line (95% CI) showing the associations between sphingosine-1-phosphate (S1P) with mean magnetic resonance imaging determined left ventricular stroke volume (LVSV), left ventricular stroke work (LVSW), heart rate (HR), left ventricular cardiac output (LVCO) and left ventricular ejection fraction (LVEF) stratified by sex (men = 457; women = 381). *Linear regression adjusted for age, body fat mass, body fat-free mass, height^2.7, systolic blood pressure, use of antihypertensive medication, glycated hemoglobin, use of hypoglycemic medication, smoking status and eGFR. Data was weighted according to subjects that did not take part in the MRI examination