Table 2.
Adjusted* ß-coefficient (95%-CI) of the associations of S1P with magnetic resonance imaging determined leftventricular and leftatrial cardiac geometry and function parameters stratified by sex (LV: men = 457; women = 381, LA: men = 421; women = 354)
| Parameter | Men ß-coefficient (95% CI), p-value |
Women ß-coefficient (95% CI), p-value |
|---|---|---|
| Left ventricular end-diastolic volume (mL) | − 18.1 (− 32.6 to − 3.66), p = 0.014 | 1.78 (− 7.34 to 10.9), p = 0.703 |
| Left ventricular end-systolic volume (mL) | − 4.63 (− 13.9 to 4.63), p = 0.327 | − 1.19 (− 7.77 to 5.40), p = 0.723 |
| Left ventricular wall-thickness (mm) | − 0.46 (− 0.89 to − 0.04), p = 0.034 | − 0.25 (− 0.58 to 0.09), p = 0.144 |
| Left ventricular mass (g) | − 16.3 (− 26.1 to − 6.55), p = 0.001 | − 0.21 (− 6.37 to 5.94), p = 0.946 |
| Left ventricular concentricity (g/mL) | − 0.02 (− 0.09 to 0.04), p = 0.510 | − 0.02 (− 0.07 to 0.03), p = 0.392 |
| Left ventricular stroke volume (mL/beat) | − 13.3 (− 22.1 to − 4.49), p = 0.003 | 3.10 (− 4.03 to 10.2), p = 0.393 |
| Left ventricular stroke work (cJ) | − 18.7 (− 30.9 to − 6.43), p = 0.003 | 5.10 (− 3.78 to 13.9), p = 0.260 |
| Heart rate (bpm) | 3.91 (− 2.20 to 10.0), p = 0.209 | − 1.72 (− 8.52 to 5.10), p = 0.619 |
| Left ventricular cardiac output (L/min) | − 0.62 (− 1.27 to 0.03), p = 0.061 | 0.08 (− 0.53 to 0.70), p = 0.800 |
| Left ventricular ejection fraction (%) | − 1.91 (− 5.00 to 1.13), p = 0.218 | 1.14 (− 2.55 to 4.82), p = 0.544 |
| Left atrial end-diastolic volume (mL) | − 12.6 (− 24.3 to − 1.03), p = 0.033 | − 3.07 (− 11.6 to 5.41), p = 0.477 |
| Left atrial end-systolic volume (mL) | − 7.42 (− 15.9 to 1.03), p = 0.085 | 2.19 (− 4.60 to 8.95), p = 0.524 |
| Left atrial stroke volume (mL/beat) | − 4.03 (− 9.85 to 1.80), p = 0.175 | − 4.29 (− 12.6 to 4.02), p = 0.311 |
| Left atrial cardiac output (L/min) | − 0.10 (0.59 to 0.40), p = 0.706 | − 0.39 (− 1.05 to 0.27), p = 0.242 |
| Left atrial ejection fraction (%) | 1.08 (− 3.12 to 5.28), p = 0.613 | − 0.34 (− 4.82 to 4.13), p = 0.880 |
A p-value p < 0.05 was considered as statistically significant and therefore highlighted in bold
*Linear regression adjusted for age, body fat mass, body fat-free mass, height2.7, systolic blood pressure, use of antihypertensive medication, glycated hemoglobin, use of hypoglycemic medication, smoking status and eGFR. Data was weighted according to subjects that did not take part in the MRI examination