Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jul 25;42(3):725–740. doi: 10.1007/s10555-023-10127-w

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 1 — miRNAs biogenesis and mechanisms of gene silencing in a nutshell. miRNAs are transcribed from DNA by RNA polymerase II /III to form single-stranded looped primary transcript (pri-miRNA). These pri-miRNAs are cleaved by Drosha and DGCR8 to release the ~ 70-nucleotides hairpin RNA called pre-miRNA which is transported to the cytoplasm via exportin-5. Next, a miRNA duplex of 22 nucleotides is generated by Dicer. This duplex is unwound into mature single-stranded mature miRNA that incorporates in the RNA-induced silencing complex (RISC) where it forms complementary pair with a certain mRNA. Depending on the degree of complementarity, the mRNA is degraded or translationally repressed. miRNAs can also be translocated to dendrites and axons