Table 2.

Compound concentrations per group are in µM following the format of Q2 (Q1–Q3). Where Q2 represents the median value of the distribution and Q1 & Q3 are the 25th & 75th percentile respectively. This format was selected as the measurements per group were not normally distributed

Compound	Control	Mild	Intermediate	Severe	Discharged	Deceased
	Median (Q1—Q3) µM
KYNA	0.042 (0.034–0.063)	0.045 (0.032–0.054)	0.051 (0.035–0.077)	0.085 (0.057–0.14)	0.052 (0.04–0.076)	0.11 (0.066–0.22)
KYN	2.2 (1.6–2.8)	1.9 (1.3–2.6)	2.9 (2–4.1)	3.6 (2.4–4.7)	2.4 (1.9–3.6)	4.3 (2.5–5)
TRP	58 (40–63)	50 (35–60)	49 (36–58)	45 (35–53)	48 (37–58)	43 (27–51)
C4-carnitine	0.13 (0.097–0.21)	0.13 (0.095–0.17)	0.15 (0.12–0.22)	0.24 (0.16–0.42)	0.15 (0.11–0.24)	0.25 (0.17–0.46)
iso-C4-carnitine	0.076 (0.055–0.13)	0.074 (0.048–0.11)	0.1 (0.056–0.17)	0.19 (0.08–0.39)	0.096 (0.056–0.19)	0.19 (0.079–0.52)
ddhC	0.065 (0.045–0.091)	0.38 (0.076–0.76)	0.8 (0.21–0.97)	0.46 (0.13–0.79)	0.39 (0.097–0.86)	0.5 (0.18–0.95)