Table 3.

List of polymer nanoparticles for targeted delivery

Modification	Payload	Therapies involved	Target cancer model	Outcome	References
Exosome	Doxorubicin	Chemotherapy	Human breast cancer cells MDA-MB-231; mouse ovarian cancer cells; breast and ovarian cancer mouse models	Cytotoxicity of doxorubicin was enhanced and drug accumulation in mouse heart was avoided	[127]
PEG, transferrin modified NP	Nucleic acids	Nucleic-acid-based therapy	Human prostate cancer lines PC3 Chronic myelogenous leukaemia cells K562	Showed higher efficiency over untargeted particles when transfect K562 leukaemia cells	[128]
Tmab modified NP	Paclitaxel	Targeted therapy, chemotherapy	Human HER2-postive breast cancer cell lines: BT474, SK-BR-3; HER2-negative cell line: MDA-MB-231	Better treatment efficacy and lower cytotoxicity to human breast epithelial cell control were exhibited	[129]
Trithiol-terminated poly-methacrylic acid modified nanorods	Fe2P	SDT, PTT	Human cervix cancer cells HeLa; non-cancerous mouse fibroblast cells L929	The nanorod was biocompatible and showed ultrasound, photothermal synergistic therapeutic properties	[130]