Table 3.
Baseline characteristics (d-dimer > 2ULN)
| Rivaroxaban (N = 43) | SOC (N = 45) | Total (N = 88) | |
|---|---|---|---|
| Age at inclusion (years) | |||
| Mean (SD) | 63.000 (14.248) | 63.911 (16.662) | 63.466 (15.447) |
| Sex | |||
| Female | 18 (41.9%) | 16 (35.6%) | 34 (38.6%) |
| Male | 25 (58.1%) | 29 (64.4%) | 54 (61.4%) |
| Weight (kg) | |||
| Mean (SD) | 85.233 (17.514) | 85.342 (16.831) | 85.287 (17.075) |
| BMI (kg/m2) | |||
| Mean (SD) | 28.763 (4.913) | 27.972 (4.120) | 28.367 (4.524) |
| Hospitalization on inclusion | |||
| No | 0 (0.0%) | 1 (2.2%) | 1 (1.1%) |
| Yes | 43 (100.0%) | 44 (97.8%) | 87 (98.9%) |
| Asthma | |||
| Yes | 3 (7.0%) | 1 (2.2%) | 4 (4.5%) |
| COPD | |||
| Yes | 2 (4.7%) | 3 (6.7%) | 5 (5.7%) |
| Diabetes mellitus | |||
| Yes | 9 (20.9%) | 6 (13.3%) | 15 (17.0%) |
| Chronic heart failure | |||
| Yes | 3 (7.0%) | 0 (0.0%) | 3 (3.4%) |
| Coronary artery disease | |||
| Yes | 5 (11.6%) | 2 (4.4%) | 7 (8.0%) |
| Hypertension | |||
| Yes | 21 (48.8%) | 25 (55.6%) | 46 (52.3%) |
| Ischemic stroke | |||
| Yes | 0 (0.0%) | 2 (4.4%) | 2 (2.3%) |
| Current smoker | |||
| No | 38 (88.4%) | 40 (88.9%) | 78 (88.6%) |
| Unknown | 3 (7.0%) | 3 (6.7%) | 6 (6.8%) |
| Yes | 2 (4.7%) | 2 (4.4%) | 4 (4.5%) |
| Ever smoked? | |||
| No | 20 (46.5%) | 21 (46.7%) | 41 (46.6%) |
| Unknown | 3 (7.0%) | 4 (8.9%) | 7 (8.0%) |
| Yes | 18 (41.9%) | 18 (40.0%) | 36 (40.9%) |
| Time from hospitalization to randomization (days) | |||
| Mean (SD) | 3.814 (4.176) | 5.114 (5.772) | 4.471 (5.060) |
| Oxygen demand on admission to the hospital? | |||
| No | 9 (20.9%) | 9 (20.0%) | 18 (20.5%) |
| Yes | 34 (79.1%) | 36 (80.0%) | 70 (79.5%) |
| Ventilation | |||
| No | 43 (100.0%) | 42 (93.3%) | 85 (96.6%) |
| Yes | 0 (0.0%) | 3 (6.7%) | 3 (3.4%) |
| Oxygen supply? | |||
| No | 5 (11.6%) | 6 (13.3%) | 11 (12.5%) |
| Yes | 38 (88.4%) | 36 (80.0%) | 74 (84.1%) |
| Oxygen application | |||
| Mask with reservoir | 0 (0.0%) | 2 (4.4%) | 2 (2.3%) |
| Mask without reservoir | 2 (4.7%) | 2 (4.4%) | 4 (4.5%) |
| Nasal cannula | 36 (83.7%) | 32 (71.1%) | 68 (77.3%) |
| Creatinine (mg/dL) | |||
| Mean (SD) | 0.914 (0.290) | 0.889 (0.237) | 0.901 (0.263) |