Table 3.

Multivariable Cox regression analysis of baseline factors associated with infusion reactions and infection

Baseline factor	Category	Reference	Infusion reactions			Infection
			HR	95% CI	p value	HR	95% CI	p value
Disease	CD	RA	1.32	0.75–2.34	0.336	0.46	0.22–0.98	0.044*
	UC	RA	2.10	1.30–3.37	0.002**	0.92	0.52–1.62	0.777
	PS	RA	1.25	0.58–2.69	0.565	0.11	0.02–0.83	0.032*
Prior biologics	Switched from IFX	Naïve	0.55	0.35–0.85	0.007**	0.57	0.36–0.89	0.014*
	Switched from other biologics	Naïve	2.06	1.30–3.26	0.002**	0.95	0.51–1.77	0.87
Sex	Male	Female	0.89	0.60–1.30	0.538	0.83	0.53–1.31	0.418
Age	In 1-year increments		0.99	0.98–1.01	0.282	1.00	0.99–1.01	0.872
BMI	In 1-kg/m2 increments			–		1.04	0.99–1.09	0.140
CRP	≥ 0.5 mg/dL	< 0.5 mg/dL	1.42	0.98–2.07	0.066		–
History of allergy	Yes	No	1.81	1.21–2.69	0.004**	1.68	1.05–2.66	0.029*
Comorbidities	Yes	No		–		2.07	1.34–3.19	0.001**
Steroid usea	Yes	No		–		1.95	1.29–2.96	0.002**

BMI body mass index, CD Crohn’s disease, CI confidence interval, CRP C-reactive protein, HR hazard ratio, PS psoriasis, RA rheumatoid arthritis, UC ulcerative colitis

*p < 0.05; **p < 0.01

^aSteroid use for the treatment of a target disease, excluding use for prophylaxis, comorbidities, or adverse drug reactions