FIG. 1.
Effect of topical administration of econazole and PC-econazole on C. albicans vaginal infection in mice. Groups of 10 estrogen-treated mice were intravaginally inoculated with 5.0 × 105 C. albicans blastoconidia. Drugs were administered once daily for five consecutive days as indicated by the arrows. The numbers of C. albicans CFU are given as the means ± SD of three separate experiments and were quantitated by culturing serial dilutions of vaginal lavage fluid collected from each mouse on alternate days. (A) time course of infection in mice receiving 20 μl of 1.0% econazole (▴), 1.0% PC-econazole (○), and excipients (■). (B) C. albicans infection kinetics in mice treated as described for panel A and subjected to deliberate vaginal washing with 100 μl of PBS 4 h after each administration of drugs.