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. 2023 Oct 18;13:17805. doi: 10.1038/s41598-023-44857-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Paclitaxel-induced cold allodynia is alleviated by NaBut. (a) 8 mg/kg, i.p. of paclitaxel or vehicle (i.p.) injections on alternative successive days (1, 3, 5, 7) to a cumulative dose of 32 mg/kg (N = 11–15 per treatment group). Paclitaxel cohorts receiving the NaBut treatment were treated twice daily with a 250 mM oral gavage of NaBut for 14 days starting on the first day of paclitaxel i.p injection, (b) cumulative time spent engaging (flicking, shaking, grooming, licking etc.) the stimulated paw after acetone application (data analyzed by two-way ANOVA, F (1, 46) = 17.40 P < 0.001) (c) behavioral intensity scores from the acetone evaporation assay graded on a scale of 0–3 in increasing intensity (data analyzed by Kruskal–Wallis test with Dunn’s post-hoc P < 0.001). Animals treated with paclitaxel showed a significant increase in cold allodynia responses relative to the saline group, indicating an increase in peripheral behavioral hypersensitivity which was attenuated in the paclitaxel + NaBut group.