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. 2023 Oct 18;14:6592. doi: 10.1038/s41467-023-42346-8

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Serology pre- and post-challenge with Delta B.1.617.2/Omicron B.1.1.529. Serum was collected 21 days post vaccination against Lineage A or infection with Delta B.1.617.2, and on 5 DPI/DPE. a Anti-spike IgG response (Lineage A spike), measured by ELISA. Whisker-plots depicting median, upper and lower quantile, min and max values, and individuals. Kruskal–Wallis test, N = 16 animals. b Cross-reactivity of the IgG response, measured by Meso QuickPlex. Violin plots depicting median, upper (75th) and lower (25th) quantiles, and individual values. Two-way ANOVA, followed by Šídák’s multiple comparisons test. N = 16. c Individual neutralizing antibody titers against Delta B.1.617.2 and Omicron B.1.1.529. Points connected by lines indicate the same animal. Delta B.1.617.2 and Omicron B.1.1.529: Two-way ANOVA, followed by Šídák’s multiple comparisons test. Groups of pre-existing immunity: Two-way ANOVA, followed by Tukey’s multiple comparisons test. N = 16. d, g Change in overall anti-spike IgG response after challenge (donors (d) and sentinels 1 (g)). Whisker-plots depicting median, upper and lower quantile, min and max values, and individual values. Change in titer is represented as Log₂ (fold change over pre-challenge value). Dotted line indicates no change. Kruskal–Wallis test, N = 6. e, h Change in cross-reactivity after challenge/re-infection. Violin plots depicting median, upper and lower quantiles, and individual values. Change in titer is represented as Log₂ (fold change over pre-challenge value). Dotted line indicates no change in titer. Two-way ANOVA, followed by Šídák’s multiple comparisons test. N = 6 (donors (e) and sentinels 1 (h)). f, i Individual neutralizing antibody titers against Delta B.1.617.2 and Omicron B.1.1.529 after challenge. Points connected by lines indicate the same animal. Delta B.1.617.2 and Omicron B.1.1.529: Two-way ANOVA, followed by Šídák’s multiple comparisons test. Groups of pre-existing immunity: Two-way ANOVA, followed by Tukey’s multiple comparisons test. N = 6 (donors (f) and sentinels 1 (=i)). black = naïve, dark blue = intramuscularly (IM) vaccinated, light blue = intranasally (IN) vaccinated, yellow = previously infected (PI). P-values stated were significant (<0.05). Source data are provided as a Source Data file.