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. 2023 Oct 18;6:1058. doi: 10.1038/s42003-023-05317-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Golden Syrian hamsters were intranasally inoculated with SARS-CoV-2 on day 0. Daily treatment started on day 1 with 1 mg/kg S-Calpeptin subcutaneously (s.c.) and 1:100 DMSO (dimethyl sulfoxide) as control. Viral load was measured at day 3, 5, and 7 post infection in lungs and trachea. a SARS-CoV-2 RNA level expressed as viral RNA copies/copies of β-actin/g of tissue. b Infectious viral particles expressed as 50% tissue culture infective dose/g of tissue. n = 5 animals per group. Values are expressed in median, interquartiles and range. Statistically significant differences (p ≤ 0.05) were determined by two-sided Mann–Whitney U-test.