Table 1.

Chemical structure of compounds and their in vitro inhibition properties.

Inhibitor	SARS-CoV-2 Mpro Ki [nM]	CatB Ki [nM]	CatK Ki [pM]	CatL Ki [pM]	CatV Ki [pM]	VERO E6 EC50 [nM]
	4500 (3900–5600)	41 ± 7/27–54	61 ± 12/37–85	131 ± 21/90–172	361 ± 47/268–454	183 ± 65
	4700 (1100–8000)	70 ± 15/39–100	50 ± 12/28–73	148 ± 19/111–185	169 ± 18/133–204	120 ± 54
	<100 [40]a	163 ± 50/63–262	91 ± 11/70–112	259 ± 27/204–314	242 ± 23/196–288	1071 ± 278

K_i values for SARS-CoV-2 M^pro inhibition are mean with 95% confidence interval. Values for cathepsin inhibition are mean with standard deviation and 95% confidence interval for K_i determination and mean with standard error for EC50 determination in VERO E6 cells.

^aK_i as reported previously⁶⁶.