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. 2023 Oct 18;13:17803. doi: 10.1038/s41598-023-45017-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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CGA pretreatment protects against MIRI in mice by inhibiting pyroptosis. (a,b) Effect of CGA on protein expression levels of pro-caspase-1 and cleaved-caspase-1 in I/R-injured mice.The protein expression levels of pro-caspase-1 and cleaved-caspase-1 were measuring by Western blotting analysis. (c,e) Effect of CGA on protein expression levels of GSDMD, cleaved N-terminal GSDMD, IL-1β and IL-18 in I/R-injured mice. The protein expression levels of GSDMD, cleaved N-terminal GSDMD, IL-1β and IL-18 were measuring by Western blotting analysis. (f,g) CGA pretreatment decreased the I/R injury-induced protein expression levels of cleaved-caspase-1 in the cytoplasm of cardiomyocytes. Immunohistochemistry was used to measure the protein expression levels of cleaved-caspase-1 and cleaved N-terminal GSDMD in the cytoplasm of cardiomyocytes. Representative images were captured using an optical microscope (×400 magnification). The data are expressed as the mean ± SD. n = 15 mice in each group. The full-length blots are presented in Supplementary Fig. 3. *P < 0.05 vs. the sham group, ^#P < 0.05 vs. the I/R group.