Table 1.

Summary of GWAS summary statistics with and without 23andMe data for seven externalizing-related disorders and behaviors

Phenotype	EXT (Karlsson Linnér et al. 2021)						Down-sampled EXT (EXT-minus-23andMe)
	Max N (EffN)	h2 (SE)	λGC	Mean χ2	Intercept	Ratio	Max N (EffN)	h2 (SE)	λGC	Mean χ2	Intercept	Ratio
ADHD	53,293 (49,017)	0.235 (0.015)	1.25	1.297	1.034	0.113	53,293 (49,017)	0.260 (0.017)	1.25	1.297	1.034	0.113
ALCP	164,684 (150,640)	0.055 (0.004)	1.15	1.174	1.013	0.073	164,684 (150,640)	0.055 (0.004)	1.15	1.174	1.013	0.073
CANN	186,875 (179,534)	0.066 (0.004)	1.23	1.267	1.026	0.098	164,192 (157,230)	0.068 (0.004)	1.22	1.245	1.028	0.113
FSEX*	357,187	0.115 (0.004)	1.62	1.869	1.036	0.041	357,187	0.115 (0.004)	1.63	1.868	1.036	0.041
NSEX	336,121	0.097 (0.004)	1.49	1.682	1.027	0.041	336,121	0.099 (0.004)	1.49	1.674	1.027	0.041
RISK	426,379	0.053 (0.002)	1.37	1.461	1.019	0.041	426,379	0.053 (0.002)	1.37	1.461	1.019	0.041
SMOK	1,251,809 (1,232,397)	0.078 (0.002)	2.33	3.152	1.126	0.058	652,520 (652,518)	0.079 (0.003)	1.73	2.062	1.037	0.035

EXT: Externalizing. Bolded rows indicate down-sampled summary statistics. EffN = sum of cohort-level effective sample sizes. The statistics reported in this table were all estimated with LD Score regression (v1.0.1) (Bulik-Sullivan et al. 2015): Heritability (h²) is on the observed scale. The genomic inflation factor, λ_GC, is the median χ² statistic divided by the expected median of the χ² distribution with 1 degree of freedom. Mean χ² is the average χ² statistic. Intercept is the estimated LD Score regression intercept. The ratio measures stratification bias, defined as (intercept − 1)/(mean χ² − 1)

ADHD attention-deficit/hyperactivity disorder; ALCP problematic alcohol use; CANN lifetime cannabis use; FSEX age at first sexual intercourse (reverse coded*); NSEX number of sexual partners; RISK risk tolerance; SMOK = lifetime tobacco initiation

*Age at first sex was reverse coded so as to expect a positive relationship with EXT and EXT-minus-23andMe