Table 2.

Association between BD-PRS and grey matter metrics of the significant clusters.

Cortical Metrics	MNI Coordinates			Cluster Size	cwp	β	Main Region	Additional Region(s)
	x	y	z
Significant clusters identified in combined sample of BD and HC
CV	−10.9	13.2	45.1	2996.86	0.002	−0.25	Left superior frontal gyrus	Caudal and rostral middle frontal gyri
CSA	−8.6	18.1	51.9	2961.54	0.03	−0.23	Left superior frontal gyrus	Caudal and rostral middle frontal gyri
CTh	−48.8	−20.4	−11.5	5381.29	<0.001	−0.32	Left superior temporal gyrus	Temporal pole; middle and inferior temporal gyri; fusiform gyrus
	42.6	−13.6	−25.9	1906.88	0.049	−0.32	Right inferior temporal gyrus	Fusiform and parahippocampal gyri
Significant clusters identified within BD
CTh	−37.4	47	−1.4	2075.28	0.03	−0.33	Left rostral middle frontal gyrus	Caudal middle frontal gyrus; parstriangularis; lateral orbitofrontal cortex
	−51.1	7.9	−15.8	2021.08	0.04	−0.33	Left superior temporal gyrus	Middle and inferior temporal gyri
	41.4	−15	−24.2	2581.51	0.01	−0.41	Right fusiform gyrus	Parahippocampal gyri
Significant clusters identified within HC
CV	−23	18.5	47.9	3985.42	<0.001	−0.46	Left superior frontal gyrus	Caudal and rostral middle frontal gyri
	21.8	0.8	51	2300.29	0.02	−0.38	Right superior frontal gyrus	Precentral, postcentral, and caudal middle frontal gyri
CSA	−23.3	16.5	47.4	3470.35	0.01	−0.45	Left superior frontal gyrus	Caudal and rostral middle frontal gyri

MNI Montreal Neurological Institute, cwp cluster-wise p value, BD bipolar disorder, HC healthy control, CV cortical volume, CSV cortical surface area, CTh cortical thickness.