Table 1.
SNPs included in regression analyses exploring the impact of pharmacogenomic variation neutrophil levels.
SNP | CHR | Gene | ALT | Main Association |
---|---|---|---|---|
rs2011425 | 2 | UGT1A4/5/6/7/8/9/10 | G | Alternative allele linked with decreased plasma norclozapine levels29. |
rs61750900 | 4 | UGT2B10 | T | Alternative allele linked with decreased plasma norclozapine levels29. |
rs1126545 | 10 | CYP2C18 | T | Alternative allele linked with increased metabolic ratio29. |
rs2472297 | 15 | CYP1A1/2 | T | Alternative allele linked with decreased plasma clozapine levels29. |
rs2814778 | 1 | ACKR1 | C | Alternative allele homozygosity (Duffy-Null genotype) linked with non-pathological baseline ANC31. |
SNPs included in regression analyses exploring the impact of pharmacogenomic variation on neutrophil levels.
SNP Single Nucleotide Polymorphism, CHR Chromosome, ALT Alternative (or Minor) allele.