Table 3.

Variables selected for each comparison and performance assessment of the classifier.

Comparison	Retained variables	Coefficient	Cutpoint	AUC	Sensitivity	Specificity	PPV	NPV
SCLC vs CTR	Batch	0.634	0.4166	0.574	0.3125	0.8824	0.7143	0.576
	Age	0.3153
	PLASMA.miR.122.5p.vs.93.5p	-0.01554
	PLASMA.miR.320b.vs.93.5p	-0.003632
	PLASMA.miR.375.3p.vs.126.3p	2.573
SCLC vs ADENO	Batch	1.091	0.5771	0.75	0.375	1	1	0.411
	PLASMA.miR.375.3p.vs.24.3p	0.5744
SCLC vs SCC	Batch	1.013	0.5494	0.833	0.375	1	1	0.375
	PLASMA.miR.375.3p.vs.126.3p	1.507
SCLC vs NSCLC	Batch	0.9479	0.4012	0.793	0.375	1	1	0.565
	PLASMA.miR.375.3p.vs.24.3p	0.3593
SCLC vs OTHER	Batch	0.9766	0.4423	0.658	0.3125	1	1	0.731
	PLASMA.miR.144.3p.vs.24.3p	0.003482
	PLASMA.miR.375.3p.vs.126.3p	1.206
SCLC stage I+II vs CTR	Batch	2.17	0.2394	0.515	0.5	0.5294	0.2	0.818
	PLASMA.miR.375.3p.vs.126.3p	-4.265
SCLC stage I+II+III vs CTR	Batch	0.5922	0.3019	0.444	0.4444	0.4118	0.2857	0.583
	PLASMA.miR.375.3p.vs.126.3p	1.239
SCLC stage IV vs CTR	Batch	-0.1454	0.3414	0.882	0.2857	0.9412	0.6667	0.761
	Age	0.4699
	Race	-0.6286
	PLASMA.miR.144.3p.vs.24.3p	0.01695
	PLASMA.miR.320b.vs.126.3p	-3.508
	PLASMA.miR.375.3p.vs.126.3p	6.354

AUC, area under the ROC curve; PPV, positive predicted value; NPV, negative predicted value.