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. 2023 Oct 5;17:1217079. doi: 10.3389/fnins.2023.1217079

Figure 1.

Figure 1

Morphometric similarity analyses of repeat ayahuasca usage. (A) Regional distribution of morphometric similarity (MS) in Santo Daime members and matched controls. (B) Case–control distributions of residual morphometric similarity, following regression of sex and age. (C) t-statistic and FDR flagged (p < 0.05) regions for differences in MS between groups (ayahuasca – controls). (D) Top – kernel density scatterplot of the mean regional MS scores of controls (x-axis) and the ayahuasca-control t-statistic (y-axis), bottom – schematic of functional implication of MS scatter plot value distribution. Lighter hues reflect higher value densities. (E) Case–control MS differences relative to Yeo functional and von Economo cytoarchitectural communities. Absolute t-statistics are displayed. Yeo abbreviations correspond to the following: VIS, visual network; DAN, dorsal attention network; SMN, somato-motor network; DA, dorsal attentional network; VA, ventral attention network; L, limbic network; FPN, fronto-parietal network; DMN, default mode network. Von Economo labels reflect the following: Prim motor, granular primary motor cortex; Asso1, granular association isocortex type I; Asso2, granular association isocortex type 2; Sec sens, secondary sensory cortex; Prim sens, primary sensory cortex; Limbic, limbic regions (allocortex including entorhinal, retrosplenial, presubicular and cingulate); Insula, insular cortex (containing granular, agranular and dysgranular regions). For all renders, local maximum values are displayed.