Table 1.

Timeline of the disease status and resulting/corresponding therapy in our case.

Age	Disease status	Therapy
15 months	NOD2 mutation discovered. Severe papular dermatitis, pruritus, arthritis, uveitis	Started on oral prednisolone 2 mg/kg/day for 8 weeks
17 months	Resolved dermatitis, pruritus, arthritis, and uveitis	Finished first course of oral steroids
19 months	Recurrence of dermatitis, pruritus, arthritis, and uveitis	Re-initiation of second course of oral prednisolone 2 mg/kg/day for 8 weeks
21 months	Resolved dermatitis, pruritus, arthritis, and uveitis	Finished second course of corticosteroids
22 months	Recurrence of dermatitis, pruritus, arthritis, and uveitis	Weaned off steroids Started on 7.5 mg methotrexate subcutaneously weekly + 1 mg folic acid orally daily
24 months	Improved dermatitis, but persistent arthritis, pruritus, and uveitis	Started 75 mg daily hydroxychloroquine
26 months	Resolved dermatitis, pruritus, arthritis, and uveitis	Hydroxychloroquine discontinued due to desire to minimize long-term macular toxicity/risk for retinopathy Continued on methotrexate 7.5 mg subcutaneously weekly
30 months	Remains free of dermatitis, pruritus, arthritis, and uveitis	Continuing 7.5 mg methotrexate subcutaneously weekly + 1 mg folic acid orally daily